Prevention of RH Haemolytic Disease

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Prevention of Rh-haemolytic Disease: a Third Report.

In two papers (Finn et al., 1961 ; Clarke et al., 1963) we described experiments which were successful in preventing Rh immunization in Rh-negative male volunteers. The basis of the procedure was to remove rapidly from the circulation previously injected chromium-tagged Rh-positive red cells by giving hightitre incomplete anti-D either as an infusion of plasma or as gamma2-globulin. In our seco...

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Rh haemolytic disease: continuing problem of management.

Eighteen patients with severe Rh haemolytic disease, all of whom underwent fetal blood sampling and intrauterine transfusion, were studied. Twelve babies survived (67%) all of whom were delivered by lower segment caesarean section. There were three intrauterine deaths resulting in late abortion, one stillbirth with trisomy 21, and two neonatal deaths (both from severe prematurity). The traditio...

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Advances in the Management of Rh Haemolytic Disease

Exchange transfusion of the newly born baby affected with Rh hemolytic diseas' was introduced by Diamond in 1947. As a result of its fuller development, an' particularly repeated exchange transfusion for severe cases, at least 95 per cent o'v live-born affected babies may be saved by this treatment (Walker, 1959). Attention ijc now being directed therefore to the prevention of stillbirth, and, ...

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Rh Haemolytic Disease of the Newborn, 1960-1961.

Before 1941, erythroblastosis foetalis was treated at Birmingham Maternity Hospital by repeated intramuscular injections of fresh blood (Braid, 1939). During the next decade infants with Rh haemolytic disease of the newborn were given repeated intravenous transfusions of Rh negative blood. The exchange transfusion was not introduced until 1950. The first three years' experience (1950-53) with t...

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Antibody protein levels in maternal sera in Rh haemolytic disease.

constituent of foetal serum, but it virtually disappears from the circulation very soon after birth and is not detectable in normal adults. The only conditions where cx1FP has been found in the sera of adult humans in significant quantities are primary hepatocellular cancer of the liver and teratocarcinomas. It has been shown that the demonstration of x1FP in the serum of adult patients can be ...

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ژورنال

عنوان ژورنال: Vox Sanguinis

سال: 1966

ISSN: 0042-9007,1423-0410

DOI: 10.1111/j.1423-0410.1966.tb04265.x